Superman and Spider-Man is an intercompany comic book jointly published by DC Comics and Marvel Comics in July 1981. Number 28 (and final) in the Marvel Treasury Edition series, it is the "spiritual sequel" to 1976's Superman vs. the Amazing Spider-Man.

Like the earlier Superman - Spider-man crossover, the issue is non-canonical, as it assumes that the heroes and their respective cities of residence, Metropolis and New York, exist in the same universe, with no explanation given as to why they had never before met or been mentioned in each other's individual stories. It also does not explicitly mention the events of the first crossover story.

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